Radiotherapy usually does not affect your routine activities or work. It actually depends on the type of radiation therapy you are receiving, how well does your body take it, how do you feel during and after the treatment and the type of work you do i.e., how stressful or strenuous is your work is. While most of the people feel well enough and no significant difficulties performing their daily activities, others may need to reduce their working hours or take time off. Your radiation therapy team can help you out regarding this and can schedule your appointments suited for your work schedules. You may also discuss this about with your employer and keep them well informed about how radiation therapy is affecting you, and how much it can affect your working hours and discuss the options of flexible hours, other shifts or taking leave.